Vaginal microbicides: detecting toxicities in vivothat paradoxically increase pathogen transmission
نویسندگان
چکیده
منابع مشابه
Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
BACKGROUND Microbicides must protect against STD pathogens without causing unacceptable toxic effects. Microbicides based on nonoxynol-9 (N9) and other detergents disrupt sperm, HSV and HIV membranes, and these agents are effective contraceptives. But paradoxically N9 fails to protect women against HIV and other STD pathogens, most likely because it causes toxic effects that increase susceptibi...
متن کاملVaginal microbicides.
The focus of this review will be to highlight articles from 2000 and up to August 2001 that demonstrate the challenges in the evaluation of candidate microbicides, and the ways in which investigators have approached these challenges.
متن کاملWomen's interest in vaginal microbicides.
CONTEXT Each year, an estimated 15 million new cases of sexually transmitted diseases (STDs), including HIV, occur in the United States. Women are not only at a disadvantage because of their biological and social susceptibility, but also because of the methods that are available for prevention. METHODS A nationally representative sample of 1,000 women aged 18-44 in the continental United Stat...
متن کاملVaginal rings for delivery of HIV microbicides
Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlle...
متن کاملThe Development of Vaginal Microbicides for the Prevention of HIV Transmission
0392 Microbicides are chemical agents used topically by women within the vagina in order to prevent infection by HIV and potentially by other enveloped viruses and sexually transmitted pathogens. Prototype microbicides are designed to be inserted prior to each act of sexual intercourse and could also be contraceptive, although most current potential microbicides are not. Several proof-of-princi...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2006
ISSN: 1471-2334
DOI: 10.1186/1471-2334-6-90